nouvelles-1 — Ingredients

Research Summary: Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given sufficient bioavailability, niacinamide exhibits antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic, and lightening effects depending on its concentration.Within a complex metabolic system, niacinamide controls the NFκB-mediated transcription of signaling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically...

Research Summary: Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to be less immunogenic, or perhaps even non-immunogenic, with a variety of physicochemical properties, there is mounting evidence that PEG causes immunogenic responses when conjugated with other materials such as proteins and nanocarriers. Under these conditions, PEG with other materials can result in the production of anti-PEG antibodies after administration.The antibodies that are induced seem to have a deleterious impact on the therapeutic efficacy of subsequently administered PEGylated...

Research Summary: In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability in cosmetic formulations. Nevertheless, the efficacy of natural antioxidants in vivo is less documented than their prooxidant properties in vivo. Plant extracts rich in vitamins, flavonoids, and phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties.Because the biological activities of natural antioxidants differ, their effectiveness in slowing the aging process remains unclear. This review article focuses on the use of natural antioxidants in skincare and the possible mechanisms underlying their desired effects,...

Research Summary: World consumers are looking for personal care products that supply multiple benefits with minimal effort. They also expect the latest technological advances to be incorporated into innovative formulations. The trend toward therapeutic cosmetics will lead to a better understanding of modern ingredients and their assessment techniques. To obtain skin care formulations with real consumer-perceivable benefits and to optimize sensory attributes, formulators are resorting to technology that until recently was exclusively used in cosmetic products. Various formulations come under special delivery systems like Vesicular, Particulate systems, and emulsions type, along with their applications, as shown in this article. This...