Research — aging

Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application of antioxidants in skin care is well accepted as an effective approach to delay the skin aging process. Methylene blue (MB), a traditional mitochondrial-targeting antioxidant, showed a potent ROS scavenging efficacy in cultured human skin fibroblasts derived from healthy donors and from patients with progeria, a genetic premature aging disease. In comparison with other widely used general and mitochondrial-targeting antioxidants, we found that MB was more effective in stimulating skin fibroblast proliferation and delaying cellular senescence. The skin irritation test, performed...

Research Summary: The role of cosmetic products is rapidly evolving in our society, with their use increasingly seen as an essential contribution to personal wellness. This suggests the necessity of a detailed elucidation of the use of nanoparticles (NPs) in cosmetics. The aim of the present work is to offer a critical and comprehensive review discussing the impact of exploiting nanomaterials in advanced cosmetic formulations, emphasizing the beneficial effects of their extensive use in next-generation products despite a persisting prejudice around the application of nanotechnology in cosmetics. The discussion here includes an interpretation of the data underlying generic information reported...

Research Summary:  Natural substances have traditionally been used in skin care for centuries. There is now an ongoing search for new natural bioactives that not only promote skin health but also protect the skin against various harmful factors, including ultraviolet radiation and free radicals. Free radicals, by disrupting defense and restoration mechanisms, significantly contribute to skin damage and accelerate aging. Natural compounds present in plants exhibit antioxidant properties and the ability to scavenge free radicals. The increased interest in plant chemistry is linked to the growing demand for plant materials as natural antioxidants. This review focuses on aromatic and medicinal...

Research Summary: Niacinamide is vitamin B3, an essential nutrient. In the body, it is converted to the co-factors NADH and NADPH, which are involved in many biochemical reactions. Dietary deficiency of this water-soluble member of the vitamin B family causes pellagra, a disease that includes dermatitis and red lesions. Pellagra caused thousands of deaths in the United States in the first half of the twentieth century, until simple dietary supplementation with this absorbable vitamin was found to cure the disorder.NAD+ and NADPH levels in skin cells decline with age. Thus, supplementing skin with the precursor to these vital co-factors has...