Our Actives

R&D · MDRN Research Archive

Sixteen actives.
Every one sourced.

Not a headline number. Sixteen ingredients across five formulas, each traced to the studies that actually back it — pulled from our own research library and cross-checked externally where needed.

16
Active ingredients
39cit.
Sources cited
217
Papers in the wider library
Cruelty-FreeNever tested on animals
V
100% VeganNo animal-derived ingredients
Pb
Paraben-FreePreserved with phenoxyethanol
The finding everything else is built on
90%

Up to 90% of premature skin aging is caused by external stressors — UV exposure, pollution, blue light, and lifestyle — not genetics or the natural passage of time. That's the case for a protection-first system, not just another routine.

Farage, M.A., Miller, K.W., Elsner, P. & Maibach, H.I. (2008). Intrinsic and extrinsic factors in skin ageing: a review. International Journal of Cosmetic Science, 30: 87–95. Read the paper →
Building on the foundational framework established in Uitto, J. (1997). Understanding Premature Skin Aging. New England Journal of Medicine, 337: 1463–1465. View on PubMed →
03 — Why it works

The evidence behind the system

Real findings from real papers — not a headline number.

Research breadth
217

Published studies in our research library, covering every active ingredient across the system.

Collagen — aggregated
19 trials

A systematic review and meta-analysis of 19 clinical trials, 1,125 women — favourable effects on skin hydration, elasticity and wrinkles.

Copper Tripeptide-1
70%

In comparative testing, outperformed vitamin C (50%) and retinoic acid (40%) for improved collagen production.

de Miranda, R.B. et al. (2021). Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. International Journal of Dermatology.  ·  Pickart, L. & Margolina, A. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide. International Journal of Molecular Sciences.
04 — Sign-off

Scientific advisory board

2 PhD scientific advisors — dermatology and cell regeneration
01 — Evidence log

Ingredient ledger

Click a row to open every source behind it — on-site studies and external ones.

02 — Reading key

How to read this

§

Two source types, one honesty rule

On-site links open a study already published on our own Research blog. External links point to the original publisher. The bars on the right show evidence weight — a full strong bar means a human clinical or RCT measuring the relevant outcome; moderate means in vitro, animal, or review-level evidence, directionally supportive but not a substitute for a human trial; weak is marked as such rather than hidden.

MDRN
R&D Archive — internal reference
Curated from a 217-paper research library