HyPrEn™ System is formed around sixteen high performing ingredients across five formulas. Each active ingredient traced to the studies that actually support it.
16
Active ingredients
42
Sources cited
217
Papers in the wider library
✓
Cruelty-FreeNever tested on animals
V
100% VeganNo animal-derived ingredients
Pb
Paraben-FreePreserved with phenoxyethanol
The findings MDRN is built on
90%
Up to 90% of premature skin aging is caused by external stressors — UV exposure, pollution, blue light, and lifestyle — not genetics or the natural passage of time.
Farage MA, Miller KW, Elsner P, Maibach HI. "Characteristics of the Aging Skin." Advances in Wound Care, 2008. — the original anchor for the externally-driven-aging figure itself.
Fisher GJ et al. "Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light." New England Journal of Medicine, 1997;337:1419–1428. — the mechanism paper: UV light directly degrades the collagen fibrils responsible for skin's strength and resilience. This is the one you asked to add.
Martic I, Jansen-Dürr P, Cavinato M. "Effects of Air Pollution on Cellular Senescence and Skin Aging." Cells, 2022;11:2220. — the other one you named ("Cavinato"). Covers the non-UV side: pollution interacting synergistically with UV to compound damage, which backs "exposure doesn't happen one stressor at a time."
Why it works
The evidence behind the system
Research breadth
217
Published studies in our research library, covering every active ingredient across the system.
Ingredient screening
470
Reviewed and assessed for skin performance suitability, trial results and safety.
Our Intellectual Property
5 formulas
Developed and owned by MDRN, built exclusively for skin performance and exposure recovery.
Sign-off
Scientific Advisory Board
Dr Imad Naasani PhD Prof Christian Sadik
Ingredient ledger
Sixteen actives. Every one sourced.
Click a row to open every source — and read why we chose it.
EctoinEnvironmental stress protection, hydration, barrier support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder
""Most actives protect skin after damage happens. Ectoin works before it changes how water sits in the skin under stress. That's the difference between defending and repairing.""
Ectoine disperses keratin and alters hydration kinetics in stratum corneum — PMC, 2021
""The one ingredient with almost no argument against it. Cheap to leave out, expensive to skip. It went in three formulas because it earns its place in all three.""
Niacinamide: A Topical Vitamin with Wide-Ranging Skin Appearance Benefits
Copper Tripeptide-1Skin conditioning and recovery support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder
""This is the ingredient that outperformed vitamin C and retinoic acid in head-to-head testing. When something beats the category standards, you use it.""
Pickart & Margolina — Regenerative and Protective Actions of the GHK-Cu Peptide, Int J Mol Sci, 2018
""Panthenol was chosen because it does several useful jobs at once. For MDRN its best for barrier recovery and useful when skin is irritated, dry, post-exercise, wind-exposed or environmentally stressed.""
A new topical panthenol-containing emollient: two RCTs on moisturization, barrier restoration and skin microflora
""Squalene production drops sharply with age noticeably after 30, and by some estimates down to a fraction of youthful levels by 50. Is a big part of why skin gets drier and rougher over time.— we're topping up what age and exposure strip out.""
Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing — PMC, 2025
""Mineral, not chemical. No debate needed on this one. For a light weight SPF it's a very safe UV filter, less chalky than Zinc and the data backs it.""
Novelty Cosmetic Filters Based on Nanomaterials Composed of Titanium Dioxide Nanoparticles
Hydrolysed CollagenHydration and skin-conditioning, particularly in the eye patches
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder
""Collagen has been broken into smaller fragments, it can bind water and form a light film on the skin. That can make skin feel smoother, softer, plumper and temporarily reduce the appearance of fine dehydration lines.Nineteen trials, over a thousand people, one conclusion. That's not a marketing number — that's a real evidence base.""
A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density — RCT, blind study
""Grape Extract → antioxidant defence against environmental oxidative stress. Byproduct of an industry that's been perfecting extraction for centuries. Turns out winemakers were sitting on a skincare ingredient the whole time.""
Chengolova, Ivanov & Godjevargova — Polyphenolic Compounds in Skins and Seeds of Four Grape Varieties, Molecules, 2023
Yarovaya et al. — Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract, J Cosmetic Dermatology, 2022
Volcanic Kaolin ClayMineral-rich oil and impurity absorption
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder
""Rich in magnesium and potassium — that's why this clay made the cut over the others. It's not just drawing out impurities, it's putting minerals back.""
Purified Montmorillonite as a Nano-Adsorbent of Potentially Toxic Elements from Environment: an overview
