Research — aging

Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death, depending on its severity and duration. Vitamin B3 is used in the synthesis of the NAD+ family of coenzymes, contributing to cellular energy metabolism and defense systems. Although nicotinamide (niacinamide) is primarily used as a nutritional supplement for vitamin B3, its pharmaceutical and cosmeceutical uses have been extensively explored.In this review, we discuss the biological activities and cosmeceutical properties of nicotinamide in consideration of its metabolic pathways. Supplementation of nicotinamide restores the cellular NAD+ pool and mitochondrial energetics, attenuates oxidative...

Research Summary: In recent decades, there has been a rising demand for anti-aging interventions aimed at postponing or potentially reversing indicators of skin aging. The use of collagen-based nutraceutical supplements has gained popularity as they have shown promise in enhancing skin health and reducing signs of aging. The aim of this randomized, placebo-controlled, blinded study was to investigate the effects of 2.5 g COLLinstant® LMW, a novel cosmeceutical containing low molecular weight (≤ 1000 Da) collagen peptides, on skin aging and health. The trial was conducted in 80 healthy women aged 30 years and older. They received a daily oral...

Research Summary:Artocarpus heterophyllus (A. heterophyllus) is one of the plants commonly used for skin care. This study aimed to formulate a clay mask preparation with the active ingredient  A. heterophyllus 3% leaf extract and evaluate its activities in repairing facial moisture, smoothness, large pores, blemishes, and wrinkles. The process of preparing the clay masks began with the extraction of Artocarpus heterophyllus leaf ethanol extracts, ensuring standardized quality. This was followed by the preparation of clay mask bases with guaranteed quality, mixing the clay mask bases with the extracts, and testing the quality, stability, and effectiveness of the skin care product....

Research Summary: The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo-ageing, the main focus of this article, is a subset of extrinsic skin ageing.The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular)...