R&D · MDRN Research Archive

Sixteen actives.
Every one sourced.

HyPrEn™ System is formed around sixteen high performing ingredients across five formulas. Each active ingredient traced to the studies that actually support it.

16
Active ingredients
42
Sources cited
217
Papers in the wider library
✓
Cruelty-FreeNever tested on animals
V
100% VeganNo animal-derived ingredients
Pb
Paraben-FreePreserved with phenoxyethanol
The findings MDRN is built on
90%

Up to 90% of premature skin aging is caused by external stressors — UV exposure, pollution, blue light, and lifestyle — not genetics or the natural passage of time.

  1. Farage MA, Miller KW, Elsner P, Maibach HI. "Characteristics of the Aging Skin." Advances in Wound Care, 2008. — the original anchor for the externally-driven-aging figure itself.
  2. Fisher GJ et al. "Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light." New England Journal of Medicine, 1997;337:1419–1428. — the mechanism paper: UV light directly degrades the collagen fibrils responsible for skin's strength and resilience. This is the one you asked to add.
  3. Martic I, Jansen-Dürr P, Cavinato M. "Effects of Air Pollution on Cellular Senescence and Skin Aging." Cells, 2022;11:2220. — the other one you named ("Cavinato"). Covers the non-UV side: pollution interacting synergistically with UV to compound damage, which backs "exposure doesn't happen one stressor at a time." 
Why it works

The evidence behind the system

Research breadth
217

Published studies in our research library, covering every active ingredient across the system.

Ingredient screening
470

Reviewed and assessed for skin performance suitability, trial results and safety.

Our Intellectual Property
5 formulas

Developed and owned by MDRN, built exclusively for skin performance and exposure recovery.

Sign-off

Scientific Advisory Board

Dr Imad Naasani PhD Prof Christian Sadik
Ingredient ledger

Sixteen actives. Every one sourced.

Click a row to open every source — and read why we chose it.

Ectoin
EctoinEnvironmental stress protection, hydration, barrier support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Most actives protect skin after damage happens. Ectoin works before it changes how water sits in the skin under stress. That's the difference between defending and repairing.""

Ectoine disperses keratin and alters hydration kinetics in stratum corneum — PMC, 2021
ExternalOpen →
Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis — randomised, double-blind multi-center trial, PubMed
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Ectoine-Hyaluronic Acid Cream May Improve Atopic Dermatitis in Children — pediatric RCT summary
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Niacinamide
NiacinamideBarrier function, tone, oil balance, skin resilience
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""The one ingredient with almost no argument against it. Cheap to leave out, expensive to skip. It went in three formulas because it earns its place in all three.""

Niacinamide: A Topical Vitamin with Wide-Ranging Skin Appearance Benefits
On-siteOpen →
Niacinamide — Mechanisms of Action and Its Topical Use in Dermatology
On-siteOpen →
Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
On-siteOpen →
Copper Tripeptide-1
Copper Tripeptide-1Skin conditioning and recovery support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""This is the ingredient that outperformed vitamin C and retinoic acid in head-to-head testing. When something beats the category standards, you use it.""

Pickart & Margolina — Regenerative and Protective Actions of the GHK-Cu Peptide, Int J Mol Sci, 2018
ExternalOpen →
Pickart et al. — GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration, BioMed Research International, 2015
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Effects of Topical Copper Tripeptide Complex on CO2 Laser-Resurfaced Skin — human clinical trial, Archives of Facial Plastic Surgery
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Panthenol
PanthenolSoothing, hydration and barrier support
2 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Panthenol was chosen because it does several useful jobs at once. For MDRN its best for barrier recovery and useful when skin is irritated, dry, post-exercise, wind-exposed or environmentally stressed.""

A new topical panthenol-containing emollient: two RCTs on moisturization, barrier restoration and skin microflora
On-siteOpen →
Skin moisturizing effects of panthenol-based formulations
On-siteOpen →
Hyaluronic Acid / Sodium Hyaluronate
Hyaluronic Acid / Sodium HyaluronateWater-binding hydration
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Skin loses water faster than it loses anything else. HA fixes this biggest problem faster than any other ingredient.""

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: literature review to clinical evidence
On-siteOpen →
Essendoubi et al. — Human skin penetration of hyaluronic acid of different molecular weights (Raman spectroscopy), Skin Research and Technology, 2016
ExternalOpen →
Update on Low Molecular Weight Hyaluronic Acid in Dermatology — scoping review, EMJ Reviews
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Squalane
SqualaneEmollience and barrier support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Squalene production drops sharply with age noticeably after 30, and by some estimates down to a fraction of youthful levels by 50. Is a big part of why skin gets drier and rougher over time.— we're topping up what age and exposure strip out.""

Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing — PMC, 2025
ExternalOpen →
Gholap et al. — Daily use of a bakuchiol and squalane-containing face serum impacts skin esthetics, CosmoDerma, 2023
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Costa et al. — Effect of squalane-based emulsion on polyphenols skin penetration, Colloids and Surfaces B, 2022
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Vitamin C
Vitamin CAntioxidant support and brighter-looking skin
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Brightening claims are usually noise. The collagen-support data is not. That's why it's in the system.""

A Review of Clinical Efficacy of Topical Vitamin C and Its Derivatives
On-siteOpen →
Efficacy of topical Vitamin C in melasma and photoaging: A systematic review
On-siteOpen →
The Roles of Vitamin C in Skin Health
On-siteOpen →
Vitamin E / Tocopherol
Vitamin E / TocopherolAntioxidant and lipid-barrier support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Pairs with Vitamin C for a reason — one recycles the other. Neither works as hard alone.""

Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract — split-face RCT
On-siteOpen →
Thiele & Ekanayake-Mudiyanselage — Vitamin E in human skin, Molecular Aspects of Medicine, 2007
ExternalOpen →
Randomized clinical trial of sunscreen with titanium dioxide plus 1% alpha-tocopherol antioxidant cream in photodamage
ExternalOpen →
Titanium Dioxide
Titanium DioxideMineral UV protection
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Mineral, not chemical. No debate needed on this one. For a light weight SPF it's a very safe UV filter, less chalky than Zinc and the data backs it.""

Novelty Cosmetic Filters Based on Nanomaterials Composed of Titanium Dioxide Nanoparticles
On-siteOpen →
Evaluation of effect of different concentrations of titanium dioxide on sun protection factor
On-siteOpen →
Randomized clinical trial of sunscreen with titanium dioxide plus antioxidants in advanced photodamage
ExternalOpen →
Aloe Vera
Aloe VeraHydration and soothing
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Oldest ingredient in the system. Still earns its place because the newer stuff hasn't replaced what it does for skin calming and hydration.""

Aloe Vera Gel Effect on Skin and Pharmacological Properties
On-siteOpen →
Uses of aloe in traditional and modern medicine
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Phytochemical Review of Aloe Vera with Emphasis on Its Cosmetic Applicability
On-siteOpen →
Hydrolysed Collagen
Hydrolysed CollagenHydration and skin-conditioning, particularly in the eye patches
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Collagen has been broken into smaller fragments, it can bind water and form a light film on the skin. That can make skin feel smoother, softer, plumper and temporarily reduce the appearance of fine dehydration lines.Nineteen trials, over a thousand people, one conclusion. That's not a marketing number — that's a real evidence base.""

A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density — RCT, blind study
On-siteOpen →
Effects of hydrolyzed collagen supplementation on skin aging: systematic review and meta-analysis
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Anti-Aging Effects of Low Molecular Weight Collagen Peptides Supplementation on Facial Wrinkles and Skin Hydration — 6-week RCT
On-siteOpen →
Trehalose
TrehaloseMoisture retention and protection against dehydration
2 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Protects skin cells the same way it protects seeds through drought. If it can do that, dehydration from a UK winter isn't a problem.""

Maeda et al. — Functional properties and skin care effects of sodium trehalose sulfate, Skin Research and Technology, 2024
ExternalOpen →
Trehalose in an Emulsion-Based Carrier: Effects on Skin Hydration and Transepidermal Water Loss, Cosmetics, 2026
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Grape Extract
Grape ExtractAntioxidant / polyphenol support
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Grape Extract → antioxidant defence against environmental oxidative stress. Byproduct of an industry that's been perfecting extraction for centuries. Turns out winemakers were sitting on a skincare ingredient the whole time.""

Chengolova, Ivanov & Godjevargova — Polyphenolic Compounds in Skins and Seeds of Four Grape Varieties, Molecules, 2023
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Yarovaya et al. — Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract, J Cosmetic Dermatology, 2022
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Clinical Trial to Evaluate the Effect of Grape Seed Extract-Loaded Hyalurosomes on Skin Wellness, MDPI, 2025
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Laminaria
LaminariaMineral-rich marine algae extract; hydration and conditioning
1 source cited
Moderate
Why we chose it — Alex Garcia, Founder

""Marine-derived, mineral-rich. It brings trace minerals to the table that land-based extracts don't — a different source""

Reshma et al. — Antioxidant and Antiaging Properties of Agar Obtained from Brown Seaweed Laminaria digitata, Evid Based Complement Alternat Med, 2022
ExternalOpen →
Activated Charcoal
Activated CharcoalAdsorption / cleansing in the clay treatment
1 source cited
Weak
Why we chose it — Alex Garcia, Founder

""Activated charcoal helps lift excess oil and surface impurities from stressed skin. Other claims are thin, but its excellent in clay""

Sajjad et al. — Cosmetic uses of activated charcoal, Int J Community Med Public Health, 2021 (review states clinical evidence remains limited)
ExternalOpen →
Volcanic Kaolin Clay
Volcanic Kaolin ClayMineral-rich oil and impurity absorption
3 sources cited
Strong
Why we chose it — Alex Garcia, Founder

""Rich in magnesium and potassium — that's why this clay made the cut over the others. It's not just drawing out impurities, it's putting minerals back.""

Purified Montmorillonite as a Nano-Adsorbent of Potentially Toxic Elements from Environment: an overview
On-siteOpen →
Unique Properties of Volcanic Ash Soils
On-siteOpen →
Use of Kaolin in the Pharmaceutical and Cosmetic Industries
On-siteOpen →